IF1 is a protein that inhibits the heat-generating reaction of metabolism. Species with more IF1 protein age slower and live longer; increasing IF1 protein in mice reduces aging as measured by an aging biomarker.

What is the science behind the IF1 moisturizer?

A quantitative, mechanistic account of aging, parameterized by experimental data, blindly predicts the lifespans of thousands of unseen species. Its causal chain is corroborated at forty different points by instrumental variable analysis. Controlling this chain is IF1 protein.

Where can I read the underlying paper?

The paper, 'IF1 Protein Controls Aging Rate', is available on bioRxiv at https://www.biorxiv.org/content/10.1101/2021.10.28.466310v4.full. Work has progressed substantially further in the same direction since publication.

How does this relate to skincare?

The IF1 skin moisturizer contains IF1 protein (or a derivative thereof), applying leading-edge anti-aging science directly to skincare.

IF1 Anti-Aging Skincare from a Scientific Breakthrough by Ph.D. Scientists

Species Longevity to Skin Longevity

Aging and looking older is unwanted.

In nature, different species have different aging rates and lifespans. So, nature knows how to modify aging rate, which we've discovered. Where more IF1 protein slows aging, which is a finding that we've bottled in our skin moisturizer called IF1.

Four-panel narrative: aging is unwanted; different species age at different rates; nature modifies aging rate; more IF1 protein slows aging, bottled in the IF1 skin moisturizer

THE SCIENCE

A bowhead whale can live centuries longer than a mouse. One of the greatest mysteries in science is how different species can have such different lifespans.

The highest level of evidence in science, the gold-standard (e.g., Einstein), is a quantitative explanation that can successfully predict.

Our quantitative, mechanistic account of aging (completely parameterized by experimental data) can blindly but faithfully predict the lifespans of thousands of unseen species. Its pre-specified causal chain is checked and corroborated at forty different points by instrumental variable analysis of experimental data, an advanced technique that can detect causality. Controlling this chain is IF1 protein; increasing IF1 protein in mice reduces aging as measured by an aging biomarker. The chance of all this occurring by chance is nearly zero (smaller than one divided by the number of atoms in the universe).

Further detail:

Five-step infographic: metabolism produces damaging by-products; a large part of metabolism generates heat to maintain 37°C body temperature; smaller mammals have more surface-area per unit mass and lose heat faster; therefore their metabolism is faster and they age faster; this heat-generating reaction is inhibited by IF1 protein, so more IF1 protein slows aging

With this scientific support, an anti-aging skin moisturizer containing IF1 protein (or a derivative thereof) is differentiated from others. Further information is in our paper titled IF1 Protein Controls Aging Rate. Although the work has progressed substantially further in the same direction since that was published.

Our IF1 moisturizer brings leading-edge anti-aging science to skincare. As part of our broader mission to improve, extend, and save lives at mass scale. Longevity — face first.

SUMMARY

Hear a 30 second summary from our founder Dr. Forrest here.

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